Have you been diagnosed with CVID? Did you know it’s the most frequest primary immunodeficiency in adults? Approximately 1 in 25,000 people in the general population have CVID. Thus it’s name- Common Variable Immune Deficiency. Even though it’s cause is unknown, several genes have been linked to it.
What are the signs you may have it?
How does your clinical immunologist determine what is going on? Especially since CVID is only 1 out of 300 types of PI?
Serum levels of IgG, IgM, IgA. ( IgG and at least one of the others must be lower than they should be for your personal levels)
Serum specific antibody levels
Antibody testing against Pneumovax
B and T cell testing
additional testing might be done based on these results.
Most are diagnosed in the 3rd or 4th decade of life. 20% are diagnosed as children – however a diagnosis is not made before 4.
Even on IgG treatment, you may still experience infections in ears, sinuses, bronchi, lungs and GI. Lymph nodes may be enlarged in neck, chest and abdomen from infection. GI symtopms are NOT uncommon. ( see my next post on SIBO)
If your replacement IgG is not sufficient- you may experience joint pain – especially in your large joints.
What addditional complications MIGHT go with CVID?
Autoimmune diseases and certain malignicies can be complications of many PI’s. They are usually lymphomas, leukemia, or GI.
You ask – what is the prognosis for CVID patients?
from the NIH:
“The long-term outlook (prognosis) and life expectancy for people with common variable immunodeficiency (CVID) varies. The prognosis largely depends on whether there is severe autoimmune disease; whether there are recurrent infections that cause structural lung damage; and the development of a malignancy (cancer). Other major factors that influence prognosis include the extent of end-organ damage and how successfully infections can be prevented.
Affected people who have only bacterial infections have a better prognosis than those with additional complications and can have nearly normal life expectancy. This is especially the case if they are diagnosed early and begin treatment soon after the onset of symptoms.”
If you have one of the other 300 PI’s – there is not as much info on them. Or even names for them. I have one of those mystery PI’s.
Hope this info helps you with your CVID.
Talk to you later!